LAUSR

Key Points Question Can imaging data be used to derive a scoring system to estimate long-term risk of hemorrhage of unruptured brain arteriovenous malformations (AVMs)? Findings In this prognostic study of 3962 patients with AVMs, 4 factors (ventricular system involvement, venous aneurysm, deep location, and exclusively deep drainage) were identified to build a scoring system to predict the rupture risk of AVMs. The scoring system had excellent performance in both the derivation and multicenter external validation cohorts and high discrimination in risk stratification of patients in the prospective follow-up cohort receiving conservative treatment management. Meaning These findings suggest that the scoring system is a reliable tool that can be used to reduce unnecessary interventions or unexpected AVM ruptures.