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Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis

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Key Points Question What are the speed and prevalence of vascular calcification (VC) progression, and how is VC progression associated with the risk of cardiovascular (CV) events and death among… Click to show full abstract

Key Points Question What are the speed and prevalence of vascular calcification (VC) progression, and how is VC progression associated with the risk of cardiovascular (CV) events and death among patients in China receiving maintenance dialysis? Findings In this cohort study of 1489 adult patients receiving maintenance dialysis, progression of total VC was observed in 86.5% of patients. Coronary artery calcification progression was associated with increases in the risk of CV events and death; consistent achievement of serum calcium, phosphorous, and intact parathyroid hormone target levels was associated with a lower risk of coronary artery calcification progression. Meaning These findings may be useful for increasing patient awareness and developing appropriate strategies to improve the management of chronic kidney disease–mineral and bone disorder in patients undergoing dialysis.

Keywords: receiving maintenance; progression; maintenance dialysis; calcification

Journal Title: JAMA Network Open
Year Published: 2023

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