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Key Points Question Do autoantibodies targeting the heart play a role in the cardiac complications of SARS-CoV-2–associated multisystem inflammatory syndrome in children (MIS-C) or COVID-19 mRNA vaccination? Findings This diagnostic… Click to show full abstract
Key Points Question Do autoantibodies targeting the heart play a role in the cardiac complications of SARS-CoV-2–associated multisystem inflammatory syndrome in children (MIS-C) or COVID-19 mRNA vaccination? Findings This diagnostic study including 20 children with MIS-C or COVID 19 vaccine–induced myocarditis and 21 adult and pediatric controls found no evidence of autoantibodies in serum of patients with MIS-C or vaccine-induced myocarditis binding donor cardiac tissue. Meaning These results suggest that anticardiac autoantibodies are unlikely to play a role in the cardiac pathology seen in MIS-C or COVID-19 vaccine–induced myocarditis.
Journal Title: JAMA Network Open
Year Published: 2023
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