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Key Points Question Does the BCG vaccine have a protective association with the risk of Alzheimer disease and related dementias (ADRD)? Findings In this cohort study of 6467 patients with… Click to show full abstract
Key Points Question Does the BCG vaccine have a protective association with the risk of Alzheimer disease and related dementias (ADRD)? Findings In this cohort study of 6467 patients with non–muscle-invasive bladder cancer, treatment with intravesical BCG vaccine was associated with a reduced risk of ADRD in the presence of death as a competing risk. However, the risk differences varied with time. Meaning The findings of this study suggest that bladder cancer treatment with BCG vaccine was associated with decreased mortality, and decreased ADRD, independently; clinical trials are required to study its efficacy beyond treatment in patients with bladder cancer.
Journal Title: JAMA Network Open
Year Published: 2023
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