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Efficacy and Safety of Rivaroxaban for Postoperative Thromboprophylaxis in Patients After Bariatric Surgery

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Key Points Question Is thromboprophylaxis with 10 mg of rivaroxaban for 7 and 28 days after bariatric surgery efficacious and safe? Findings In this randomized clinical trial, 272 patients undergoing… Click to show full abstract

Key Points Question Is thromboprophylaxis with 10 mg of rivaroxaban for 7 and 28 days after bariatric surgery efficacious and safe? Findings In this randomized clinical trial, 272 patients undergoing bariatric surgery were assigned to 10 mg of rivaroxaban for 7 or 28 days. Overall, a single asymptomatic thromboembolic event (0.4%) occurred in a patient undergoing sleeve gastrectomy in the long prophylaxis group, and major bleeding and clinically relevant nonmajor bleeding events occurred in 5 patients (1.9%). Meaning This trial found that thromboembolic prophylaxis with 10 mg of rivaroxaban was efficacious and safe after bariatric surgery.

Keywords: surgery; rivaroxaban postoperative; postoperative thromboprophylaxis; efficacy safety; bariatric surgery; safety rivaroxaban

Journal Title: JAMA Network Open
Year Published: 2023

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