LAUSR

Key Points Question Do the symptom profiles among children with SARS-CoV-2 infection evaluated in tertiary care emergency departments differ by variant type? Findings In this multicenter Canadian cohort study of 1440 children with SARS-CoV-2 infection, those with Alpha variant infection reported the fewest core COVID-19 symptoms, while those with Omicron variant infection reported more fever, lower respiratory tract, and systemic symptoms than those infected by other variants. Hospitalization and intensive care admission rates were comparable across variants. Meaning Although the characteristics of presenting symptoms have changed as the SARS-CoV-2 virus has evolved, the proportions of infected children experiencing undesirable outcomes has remained stable.