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Key Points Question What is the estimated vaccine effectiveness (VE) associated with first-generation COVID-19 mRNA vaccines against medically attended COVID-19 during Omicron BA.4 and BA.5 sublineage predominance? Findings This case-control… Click to show full abstract
Key Points Question What is the estimated vaccine effectiveness (VE) associated with first-generation COVID-19 mRNA vaccines against medically attended COVID-19 during Omicron BA.4 and BA.5 sublineage predominance? Findings This case-control study included 82 229 emergency department or urgent care encounters and 21 007 hospitalizations for COVID-19–like illness. Among hospitalized patients, estimated 3-dose VE was 68% for those with the third dose 7 to 119 days prior, but was lower by 120 days or longer after vaccination (VE, 36%). Meaning These findings suggest that first-generation COVID-19 mRNA vaccines were associated with protection against COVID-19 during the Omicron BA.4/BA.5 sublineage-predominant periods but protection declined over time.
Journal Title: JAMA Network Open
Year Published: 2023
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