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Development of Osteoarthritis in Adults With Type 2 Diabetes Treated With Metformin vs a Sulfonylurea

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Key Points Question Is metformin use associated with incidence of osteoarthritis (OA)? Findings In this cohort study including 41 874 time-conditional propensity score–matched patients using metformin or a sulfonylurea, those treated… Click to show full abstract

Key Points Question Is metformin use associated with incidence of osteoarthritis (OA)? Findings In this cohort study including 41 874 time-conditional propensity score–matched patients using metformin or a sulfonylurea, those treated with metformin had a lower estimated risk of developing OA. Meaning These findings suggest that metformin use was associated with a lower incidence of OA, and future interventional studies with metformin for preventing OA could be considered.

Keywords: osteoarthritis adults; development osteoarthritis; metformin sulfonylurea; treated metformin

Journal Title: JAMA Network Open
Year Published: 2023

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