LAUSR

Key Points Question What is the cost-effectiveness of mailing human papillomavirus self-sampling kits relative to usual care for increasing cervical cancer screening rates among underscreened female members of an integrated US health care system? Findings In this economic evaluation involving 19 851 female participants from a randomized clinical trial, incremental cost-effectiveness ratios for increased screening uptake ranged from $86 to $146 per additional completed screening. Meaning These findings suggest that within US-based private integrated health care systems, mailing human papillomavirus self-sampling kits to individuals who are overdue for cervical cancer screening is cost-effective and may be an efficient outreach strategy to increase screening rates among eligible women.