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Concordance and Discrepancies Among 5 Creatinine-Based Equations for Assessing Estimated Glomerular Filtration Rate in Older Adults

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Key Points Question Can the 5 most common estimated glomerular filtration rate (eGFR) equations be used interchangeably among older adults? Findings In this cohort study including 3094 participants, different creatinine-based… Click to show full abstract

Key Points Question Can the 5 most common estimated glomerular filtration rate (eGFR) equations be used interchangeably among older adults? Findings In this cohort study including 3094 participants, different creatinine-based equations provided divergent estimates of eGFR, with the Berlin Initiative Study equation having the highest prognostic accuracy for 15-year all-cause mortality. The differences between equations were not consistent across levels of calf circumference, body mass index, and age, suggesting that these factors may be potential sources of the observed discrepancies. Meaning These results suggest that clinicians and researchers should carefully consider their choice of equation when monitoring kidney function in old age.

Keywords: glomerular filtration; filtration rate; older adults; estimated glomerular; based equations; creatinine based

Journal Title: JAMA Network Open
Year Published: 2023

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