LAUSR

Key Points Question Are positive and negative expectations prior to COVID-19 vaccination associated with systemic adverse effects in individuals receiving their second dose of COVID-19 vaccines? Findings In this cohort study of 1678 participants, expectations of low benefit and high adverse effects, the tendency to catastrophize instead of normalize benign bodily sensations, and prior negative experiences were associated with vaccination adverse effects. Meaning These finding suggest that risk factors for nocebo effects exist that can be assessed prior to vaccination and in some cases (ie, negative expectations) can potentially be changed via expectation management strategies.