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Prevalence and Characteristics Associated With Post–COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults

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Key Points Question What are the prevalence and associated risk factors of post–COVID-19 condition (PCC) in young people after mild acute infection? Findings This cohort study included 382 SARS-CoV-2–positive individuals… Click to show full abstract

Key Points Question What are the prevalence and associated risk factors of post–COVID-19 condition (PCC) in young people after mild acute infection? Findings This cohort study included 382 SARS-CoV-2–positive individuals and a control group of 85 SARS-CoV-2–negative individuals aged 12 to 25 years who were assessed at the early convalescent stage and at 6-month follow-up. When applying the World Health Organization case definition of PCC, prevalence at 6 months was 49%, but was also comparably high (47%) in the control group. PCC was not associated with biological markers specific to viral infection, but with initial symptom severity and psychosocial factors. Meaning These findings suggest that persistent symptoms in this age group are related to factors other than SARS-CoV-2 infection, and therefore question the usefulness of the WHO case definition of PCC.

Keywords: prevalence; post covid; pcc; covid condition; sars cov

Journal Title: JAMA Network Open
Year Published: 2023

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