LAUSR

Key Points Question Are hypertension and blood pressure change in early adulthood associated with late-life brain health, and is there variation by sex? Findings In this cohort study of 427 adults 50 years and older, hypertension and increasing blood pressure in early adulthood were associated with lower mean regional brain volumes and poorer white matter integrity in late life. These associations were stronger in men compared with women for some regions. Meaning These findings suggest that prevention and treatment of hypertension in early adulthood has important implications for late-life brain health and may be especially important for men.