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Key Points Question Are molecular defects more common in newborns in the neonatal intensive care unit (NICU) conceived by assisted reproductive technology (ART) than in naturally conceived neonates? Findings In… Click to show full abstract
Key Points Question Are molecular defects more common in newborns in the neonatal intensive care unit (NICU) conceived by assisted reproductive technology (ART) than in naturally conceived neonates? Findings In this cross-sectional analysis of infants in NICUs for whom genetic analysis was completed, there was no significant difference in diagnoses of genetic conditions between those conceived with ART and those conceived unassisted (10.1% vs 13.2%). The proportion of de novo variants was also not significantly different. Meaning This study suggests that in the NICU, the overall molecular diagnostic yield and the incidence of de novo variants were similar between live-born neonates conceived with ART and naturally conceived neonates.
Journal Title: JAMA Network Open
Year Published: 2023
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