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Cardiovascular Outcomes and Mortality After Bariatric Surgery in Patients With Nonalcoholic Fatty Liver Disease and Obesity

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Key Points Question Is bariatric surgery associated with the incidence of major adverse cardiovascular events or all-cause of mortality among patients with nonalcoholic fatty liver disease (NAFLD) and obesity? Findings… Click to show full abstract

Key Points Question Is bariatric surgery associated with the incidence of major adverse cardiovascular events or all-cause of mortality among patients with nonalcoholic fatty liver disease (NAFLD) and obesity? Findings In this cohort study of 152 394 patients with NAFLD and obesity (including 4693 patients who underwent bariatric surgery and 147 701 patients in the nonsurgical control group), bariatric surgery was significantly associated with lower risks of major adverse cardiovascular events and all-cause mortality. These outcomes were consistent at follow-up durations of 1, 3, 5, and 7 years. Meaning These findings suggest that bariatric surgery was associated with a substantially lower risk of incidents of major adverse cardiovascular events and all-cause mortality in patients with NAFLD and obesity.

Keywords: nonalcoholic fatty; patients nonalcoholic; surgery; mortality; obesity; bariatric surgery

Journal Title: JAMA Network Open
Year Published: 2023

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