LAUSR

Key Points Question Is the use of anakinra plus the standard of care effective compared with the standard of care alone in reducing the probability of requiring mechanical ventilation among patients with severe COVID-19 pneumonia? Findings In this randomized clinical trial with 179 patients, the proportion of patients not requiring mechanical ventilation up to day 15 was not significantly different between groups (77.1% for anakinra group vs 85.9% for standard of care group). Meaning This study did not find evidence of effectiveness of anakinra vs the standard of care in reducing the need for mechanical ventilation among patients with severe COVID-19 pneumonia, and future research should assess anakinra in patients with less-severe pneumonia.