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Key Points Question What are the frequency and risk of adverse events (AEs) developing in patients with epilepsy who are using cannabidiol (CBD)? Findings In this systematic review and meta-analysis,… Click to show full abstract
Key Points Question What are the frequency and risk of adverse events (AEs) developing in patients with epilepsy who are using cannabidiol (CBD)? Findings In this systematic review and meta-analysis, the frequency of any grade AEs in patients with epilepsy was more than 2 times higher for those using CBD than for those receiving placebo. The risks of any grade AEs, severe grade AEs, serious AEs, AEs leading to discontinuation, and AEs leading to dose reduction were significantly higher in patients receiving CBD than for those receiving placebo. Meaning The treatment of patients with epilepsy using CBD was associated with the development of several types of AEs.
Journal Title: JAMA Network Open
Year Published: 2023
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