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Long-term Risk of Epilepsy Following Invasive Group B Streptococcus Disease in Neonates in Denmark

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Key Points Question Is neonatal invasive Group B Streptococcus (iGBS) sepsis or meningitis associated with increased risk of epilepsy? Findings This cohort study of children born in Denmark from 1997… Click to show full abstract

Key Points Question Is neonatal invasive Group B Streptococcus (iGBS) sepsis or meningitis associated with increased risk of epilepsy? Findings This cohort study of children born in Denmark from 1997 through 2017 found children diagnosed with iGBS meningitis were associated with a significantly higher risk of epilepsy than the matched comparison cohort. The cumulative risk of epilepsy for iGBS sepsis resembled that of the comparison cohort. Meaning These findings suggest that epilepsy should be added to the list of neurological outcomes following iGBS disease in early infancy, especially meningitis.

Keywords: invasive group; risk; risk epilepsy; group streptococcus

Journal Title: JAMA Network Open
Year Published: 2023

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