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Key Points Question Are separate, item-based measures of unawareness or heightened awareness of memory function associated with future progression from preclinical to symptomatic Alzheimer disease? Findings In this cohort study… Click to show full abstract
Key Points Question Are separate, item-based measures of unawareness or heightened awareness of memory function associated with future progression from preclinical to symptomatic Alzheimer disease? Findings In this cohort study of 436 older adults, worse unawareness scores were associated with a significantly higher hazard of clinical progression, with no significant results found for the heightened awareness or traditional awareness measures. Meaning In this study, unawareness, rather than heightened awareness, was strongly associated with future clinical progression; isolating this dimension could provide greater sensitivity and specificity in investigation of awareness in Alzheimer disease.
Journal Title: JAMA Network Open
Year Published: 2023
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