LAUSR

Key Points Question Does perioperative administration of adjunctive esketamine during cesarean delivery prevent postpartum depression? Findings In this randomized clinical trial of 298 pregnant women who underwent elective cesarean delivery, intravenous administration of esketamine significantly decreased the incidence of screened positivity for postpartum depression and improved depressive symptoms during the early postpartum period. Meaning This study suggests that perioperative adjunctive esketamine during cesarean delivery mitigates depressive symptoms, although the effect is transient and preoperative assessment of the mental status of patients should be a concern.