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Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia

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Key Points Question Do amyloid positron emission tomography (PET) positivity rates differ across racial and ethnic groups with mild cognitive impairment (MCI) or dementia? Findings In this cohort study of… Click to show full abstract

Key Points Question Do amyloid positron emission tomography (PET) positivity rates differ across racial and ethnic groups with mild cognitive impairment (MCI) or dementia? Findings In this cohort study of 17 107 Medicare beneficiaries with MCI or dementia, the proportion of amyloid positive PET scans was greater among White participants compared with Black and Asian participants. When racial and ethnic groups were matched by social and demographic factors, the proportion of amyloid positive PET scans was greater among White participants compared with Hispanic and Asian participants but not compared with Black participants. Meaning The results of this study showed differences in rates of amyloid PET positivity among racial and ethnic groups; these findings may reflect differences in underlying etiology of cognitive impairment between groups.

Keywords: mild cognitive; pet positivity; racial ethnic; cognitive impairment

Journal Title: JAMA Neurology
Year Published: 2022

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