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Key Points Question Is there characteristic microbiota in nasopharyngeal carcinoma (NPC) tissues and, if so, is it associated with prognosis? Findings In this multicenter cohort study including 802 patients with… Click to show full abstract
Key Points Question Is there characteristic microbiota in nasopharyngeal carcinoma (NPC) tissues and, if so, is it associated with prognosis? Findings In this multicenter cohort study including 802 patients with NPC, we confirmed the existence of microbiota within NPC tissues, which mainly originated from the nasopharynx. Intratumoral bacterial load was associated with poor survival in patients with NPC and was negatively associated with T-lymphocyte infiltration. Meaning The results suggest that the intratumoral bacterial load may be a reliable prognostic indicator for patients with NPC.
Journal Title: JAMA Oncology
Year Published: 2022
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