LAUSR

Key Points Question Does an intervention consisting of machine learning mortality predictions and behavioral nudges to oncology clinicians have an impact on serious illness conversations (SICs) and end-of-life outcomes among patients with cancer? Findings In this randomized clinical trial that included 20 506 patients with cancer (for a total of 41 021 encounters), the intervention led to a significant increase in SICs, from 3.4% to 13.5%, among encounters with patients at high risk of death while decreasing rates of end-of-life systemic therapy from 10.4% to 7.5%. Meaning These results suggest that a machine learning–based behavioral intervention can lead to an increase in SICs and reduction in end-of-life systemic therapy among outpatients with cancer.