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Association of a Chronic Stress Biomarker With Advanced Development of Breast and Testicular Volume The actual biologic pathways linking early childhood adversity to pubertal development are difficult to uncover.1 Daily,… Click to show full abstract
Association of a Chronic Stress Biomarker With Advanced Development of Breast and Testicular Volume The actual biologic pathways linking early childhood adversity to pubertal development are difficult to uncover.1 Daily, chronic activation of the hypothalamic-pituitary-adrenal axis might be one of the possible mechanisms, which unfolds slowly over months and years compared with the less-frequently deployed acute stress response. Hair cortisol concentration (HCC), representative of chronic stress over several months, would elucidate this finding.2 It is increasingly used as a biological marker of chronic stress.3 Virtually all attempts to link adversity with male pubertal development have proven unsuccessful.4 This study examines the correlation of HCC with testicular volume and breast development among boys and girls aged 6 to 9 years old.
Journal Title: JAMA Pediatrics
Year Published: 2017
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