LAUSR

Key Points Question What are the clinical outcomes and associated factors among children and adolescents hospitalized with COVID-19 in sub-Saharan Africa? Findings In this cohort study of 469 children and adolescents hospitalized with COVID-19 in 6 sub-Saharan African countries, morbidity and mortality were substantially higher than reported among those in non-African settings and were independently associated with age younger than 1 year and select noncommunicable disease comorbidities. Meaning This study’s findings may have implications for clinical practice and health policy regarding pediatric COVID-19 in African countries; given their high risk of adverse outcomes, COVID-19 vaccination and therapeutic interventions are needed for African children and adolescents.