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Key Points Question Are there etiological associations between clinical heterogeneity in participants with bipolar disorder and components of genetic liability that are shared between schizophrenia, bipolar disorder, and major depressive… Click to show full abstract
Key Points Question Are there etiological associations between clinical heterogeneity in participants with bipolar disorder and components of genetic liability that are shared between schizophrenia, bipolar disorder, and major depressive disorder and components that differentiate between these disorders? Findings In this genetic association study including 4429 participants, mania, psychosis, and depression were associated with the components of genetic liability differentiating bipolar disorder, major depressive disorder, and schizophrenia, respectively. The shared liability component was associated with mania. Meaning This study advances understanding of etiological heterogeneity in individuals with bipolar disorder by showing clinical heterogeneity of bipolar disorder is underpinned by etiological heterogeneity linked to components of differentiating genetic liability that reflects the symptomatology of the cognate disorders.
Journal Title: JAMA Psychiatry
Year Published: 2022
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