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Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System

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This cross-sectional study benchmarks the penetrance of current neuropsychiatric polygenic risk scores in the Veterans Health Administration health care system, and explores associations between polygenic risk scores and broad categories… Click to show full abstract

This cross-sectional study benchmarks the penetrance of current neuropsychiatric polygenic risk scores in the Veterans Health Administration health care system, and explores associations between polygenic risk scores and broad categories of human disease via phenome-wide association studies.

Keywords: care system; risk scores; health care; polygenic risk

Journal Title: JAMA Psychiatry
Year Published: 2022

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