LAUSR

Key Points Question Are longitudinal antidepressant fill trajectories during pregnancy associated with postpartum psychiatric outcomes? Findings In this cohort study of 57 934 pregnancies and 4 antidepressant fill trajectory groups in Denmark and Norway, early discontinuation and late discontinuation (short-term use) of antidepressants during pregnancy were associated with a decrease in initiating psycholeptics and having psychiatric emergencies post partum. Compared with continuing antidepressants during pregnancy, late discontinuation (previously stable use) was associated with an elevated moderate probability of postpartum psycholeptic initiation. Meaning The findings suggest that for women with severe mental illnesses and currently receiving stable treatment, continuing antidepressant treatment during pregnancy may be beneficial.