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Real-time Tracking and Classification of Tumor and Nontumor Tissue in Upper Gastrointestinal Cancers Using Diffuse Reflectance Spectroscopy for Resection Margin Assessment

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Key Points Question Can the development of a diffuse reflectance spectroscopy (DRS) probe aid cancer margin assessment in esophageal and gastric cancer surgery? Findings In this validation study including 37… Click to show full abstract

Key Points Question Can the development of a diffuse reflectance spectroscopy (DRS) probe aid cancer margin assessment in esophageal and gastric cancer surgery? Findings In this validation study including 37 patients, the development of a DRS probe and tracking system showed that machine learning can provide real-time discrimination of normal and cancer tissue with high diagnostic accuracy of 93.9% and 96.2% for gastric and esophageal specimens, respectively. Meaning This study highlights the potential for the DRS system to be used intraoperatively to aid cancer margin assessment in real time.

Keywords: diffuse reflectance; spectroscopy; real time; margin assessment

Journal Title: JAMA Surgery
Year Published: 2022

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