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Autophagy was discovered more than half a century ago. In the early days, autophagy was studied mostly through the use of biochemical methods and electron microscopy. In the 1990s, yeast… Click to show full abstract
Autophagy was discovered more than half a century ago. In the early days, autophagy was studied mostly through the use of biochemical methods and electron microscopy. In the 1990s, yeast genetics was introduced to this field and brought about an exponential expansion. The 2016 Nobel Prize in Physiology or Medicine was eventually awarded to the scientist who spearheaded the rapid development of the field: Yoshinori Ohsumi. Here, I describe in a Nutshell how the autophagy machinery was discovered and how the autophagy research field has grown following the breakthroughs from yeast studies.
Journal Title: FEBS Letters
Year Published: 2017
Link to full text (if available)
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