LAUSR

Sortilin 1 (Sort1) is a trafficking receptor that has been implicated in the regulation of plasma cholesterol in humans and mice. Here, we use metabolomics and hyperinsulinemic‐euglycemic clamp approaches to obtain further understanding of the in vivo effects of Sort1 deletion on diet‐induced obesity as well as on adipose lipid and glucose metabolism. Results show that Sort1 knockout (KO) does not affect Western diet‐induced obesity nor adipose fatty acid and ceramide concentrations. Under the basal fasting state, chow‐fed Sort1 KO mice have decreased adipose glycolytic metabolites, but Sort1 deletion does not affect insulin‐stimulated tissue glucose uptake during the insulin clamp. These results suggest that Sort1 loss‐of‐function in vivo does not affect obesity development, but differentially modulates adipose glucose metabolism under fasting and insulin‐stimulated states.