Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signaling receptor glycoprotein 130 (gp130).… Click to show full abstract
Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signaling receptor glycoprotein 130 (gp130). The structural details as well as the exact physiological role of this interaction remains unclear. Here, we describe the structural details of the SEA-gp130 complex by combining cross-linking mass spectrometry and computational modelling. Interestingly, SEA is not able to bind gp130-homologues from rat and mouse. Our data suggests that SEA may interact with human gp130 in a different manner than other known gp130-ligands. Moreover, the fact that SEA does not bind mouse or rat gp130 suggests that SAgs have additional mechanisms of action in humans.
Journal Title: FEBS letters
Year Published: 2022
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