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Multiscale network analysis identifies potential receptors for SARS‐CoV‐2 and reveals their tissue‐specific and age‐dependent expression

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The coronavirus disease 2019 (COVID‐19) pandemic has affected tens of millions of individuals and caused hundreds of thousands of deaths worldwide. Here, we present a comprehensive, multiscale network analysis of… Click to show full abstract

The coronavirus disease 2019 (COVID‐19) pandemic has affected tens of millions of individuals and caused hundreds of thousands of deaths worldwide. Here, we present a comprehensive, multiscale network analysis of the transcriptional response to the virus. In particular, we focused on key regulators, cell receptors, and host processes that were hijacked by the virus for its advantage. ACE2‐controlled processes involved CD300e (a TYROBP receptor) as a key regulator and the activation of IL‐2 pro‐inflammatory cytokine signaling. We further investigated the age dependency of such receptors in different tissues. In summary, this study provides novel insights into the gene regulatory organization during the SARS‐CoV‐2 infection and the tissue‐specific, age‐dependent expression of the cell receptors involved in COVID‐19.

Keywords: age; tissue specific; specific age; network analysis; multiscale network; sars cov

Journal Title: FEBS Letters
Year Published: 2023

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