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Bicarbonate transport is a pre‐existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic… Click to show full abstract
Bicarbonate transport is a pre‐existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade.
Keywords:
bicarbonate transport;
antitumour immunity;
cancer
Journal Title: Molecular Oncology
Year Published: 2023
Link to full text (if available)
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Journal Title: Molecular Oncology
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!