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Neuroprotective effects of FK866 against traumatic brain injury: Involvement of p38/ERK pathway

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FK866 is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), which exhibits neuroprotective effects in ischemic brain injury. However, in traumatic brain injury (TBI), the role and mechanism of FK866 remain unclear.… Click to show full abstract

FK866 is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), which exhibits neuroprotective effects in ischemic brain injury. However, in traumatic brain injury (TBI), the role and mechanism of FK866 remain unclear. The present research was aimed to investigate whether FK866 could attenuate TBI and clarified the underlying mechanisms.

Keywords: traumatic brain; neuroprotective effects; effects fk866; brain injury; brain

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2020

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