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MDS‐criteria for clinical diagnosis of progressive supranuclear palsy (PSP) were recently published, their usability in a classical clinical setting is yet unknown. We retrospectively applied the new criteria using PSP… Click to show full abstract
MDS‐criteria for clinical diagnosis of progressive supranuclear palsy (PSP) were recently published, their usability in a classical clinical setting is yet unknown. We retrospectively applied the new criteria using PSP patients’ case files. Assignment of PSP diagnosis according to the MDS‐criteria was possible in 57/80 cases. The main difference to former specialist classification was a lower phenotype diversity and higher representation of PSP‐RS. Furthermore, we examined those patients’ brain MRIs. While neuroradiologists’ reports were suggestive of PSP only in 11/62, the analysis of a blinded rater revealed pathological midbrain‐to‐pons‐ratio in 40/62 implying this imaging feature is often missed.
Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2020
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