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Relation of plasma β‐amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study

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Cerebral microbleeds (CMBs) are associated with higher risk of stroke and dementia, predating clinical diagnosis by several years. CMB are considered markers of cerebral small vessel disease (CSVD): hypertensive (deep… Click to show full abstract

Cerebral microbleeds (CMBs) are associated with higher risk of stroke and dementia, predating clinical diagnosis by several years. CMB are considered markers of cerebral small vessel disease (CSVD): hypertensive (deep CMB) and cerebral amyloid angiopathy (lobar CMB). We related plasma β‐Amyloid (40, 42 and their ratio), clusterin, and tau levels to CMB to elucidate their role as biomarkers for the angiopathies represented by CMB.

Keywords: amyloid clusterin; clusterin tau; plasma amyloid; relation plasma; cerebral microbleeds

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2020

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