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Phospho‐specific plasma p‐tau181 assay detects clinical as well as asymptomatic Alzheimer's disease

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Plasma phosphorylated‐tau‐181 (p‐tau181) reliably detects clinical Alzheimer's disease (AD) as well as asymptomatic amyloid‐β (Aβ) pathology, but is consistently quantified with assays using antibody AT270, which cross‐reacts with p‐tau175. This… Click to show full abstract

Plasma phosphorylated‐tau‐181 (p‐tau181) reliably detects clinical Alzheimer's disease (AD) as well as asymptomatic amyloid‐β (Aβ) pathology, but is consistently quantified with assays using antibody AT270, which cross‐reacts with p‐tau175. This study investigates two novel phospho‐specific assays for plasma p‐tau181 and p‐tau231 in clinical and asymptomatic AD.

Keywords: well asymptomatic; alzheimer disease; detects clinical; plasma tau181; phospho specific

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2022

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