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High‐dose IgG suppresses local inflammation and facilitates functional recovery after olfactory system injury

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Head trauma can be a cause of refractory olfactory dysfunction due to olfactory nervous system injury. Anti‐inflammatory treatment using steroids or anti‐cytokine agents is known to contribute to functional recovery… Click to show full abstract

Head trauma can be a cause of refractory olfactory dysfunction due to olfactory nervous system injury. Anti‐inflammatory treatment using steroids or anti‐cytokine agents is known to contribute to functional recovery of the central and peripheral nervous systems in injury models, while there is a concern that they can induce adverse reactions. The present study examines if high‐dose immunoglobulin G (IgG) can facilitate olfactory functional recovery following injury.

Keywords: system injury; injury; functional recovery; high dose

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2022

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