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Scientific rationale for a higher dose of nusinersen

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The long‐term favorable safety profile of nusinersen provides an opportunity to consider a higher dose. We report on the relationships between nusinersen cerebrospinal fluid (CSF) exposure, biomarker levels, and clinical… Click to show full abstract

The long‐term favorable safety profile of nusinersen provides an opportunity to consider a higher dose. We report on the relationships between nusinersen cerebrospinal fluid (CSF) exposure, biomarker levels, and clinical efficacy.

Keywords: neurology; higher dose; dose nusinersen; rationale higher; scientific rationale

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2022

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