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Corneal confocal microscopy to detect early immune‐mediated small nerve fibre loss in AL amyloidosis

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Light chain (AL) amyloidosis is a life‐threatening disorder characterised by extracellular deposition of amyloid leading to dysfunction of multiple organs. Peripheral nerve involvement, particularly small fibre neuropathy, may be associated… Click to show full abstract

Light chain (AL) amyloidosis is a life‐threatening disorder characterised by extracellular deposition of amyloid leading to dysfunction of multiple organs. Peripheral nerve involvement, particularly small fibre neuropathy, may be associated with poorer survival. Corneal confocal microscopy (CCM) is a rapid and non‐invasive imaging technique to quantify corneal small nerve fibres and immune cells in vivo. We aimed to evaluate CCM as a tool for early diagnosis of peripheral nerve involvement in AL amyloidosis.

Keywords: small nerve; corneal confocal; microscopy; nerve; confocal microscopy; amyloidosis

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2022

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