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Copy number variations across the blood–brain barrier in multiple sclerosis

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Multiple sclerosis (MS) is a neuroinflammatory disease where immune cells cross the blood–brain barrier (BBB) into the central nervous system (CNS). What predisposes these immune cells to cross the BBB… Click to show full abstract

Multiple sclerosis (MS) is a neuroinflammatory disease where immune cells cross the blood–brain barrier (BBB) into the central nervous system (CNS). What predisposes these immune cells to cross the BBB is still unknown. Here, we examine the possibility that genomic rearrangements could predisposespecific immune cells in the peripheral blood to cross the BBB and form sub‐populations of cells involved in the inflammatory process in the CNS.

Keywords: blood; blood brain; multiple sclerosis; brain barrier

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2022

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