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Metabolome and transcriptome analysis on muscle of sporadic inclusion body myositis

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Sporadic inclusion body myositis (sIBM) is the most common acquired myopathy in patients older than 50 years of age. sIBM is hardly responds to any immunosuppressing theraphies, and its pathophysiology remains… Click to show full abstract

Sporadic inclusion body myositis (sIBM) is the most common acquired myopathy in patients older than 50 years of age. sIBM is hardly responds to any immunosuppressing theraphies, and its pathophysiology remains elusive. This study aims to explore pathogenic pathways underlying sIBM and identify novel therapeutic targets using metabolomic and transcriptomic analyses.

Keywords: inclusion body; sporadic inclusion; body myositis; metabolome transcriptome

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2022

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