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Neurofilament light chain levels predict encephalopathy and outcome in community‐acquired pneumonia

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Serum neurofilament light chain (sNfL) is a biomarker for neuroaxonal damage and has been found to be elevated in several neurological diseases with neuronal destruction. New onset of confusion is… Click to show full abstract

Serum neurofilament light chain (sNfL) is a biomarker for neuroaxonal damage and has been found to be elevated in several neurological diseases with neuronal destruction. New onset of confusion is a hallmark of severity in infections. The objective of this study was to determine whether sNfL levels are increased in patients with community‐acquired pneumonia (CAP) and if increased sNfL levels are associated with disease‐associated confusion or disease severity.

Keywords: neurofilament light; light chain; acquired pneumonia; community acquired

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2022

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