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MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging

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White matter damage is a feature of Alzheimer's disease, yet little is known about how facets of the Alzheimer's disease process relate to key features of white matter structure. We… Click to show full abstract

White matter damage is a feature of Alzheimer's disease, yet little is known about how facets of the Alzheimer's disease process relate to key features of white matter structure. We examined the association of Alzheimer's disease (Aß42/40 ratio; pTau181), neuronal injury (NfL), and reactive astrogliosis (GFAP) biomarkers with MRI measures of myelin content and axonal density.

Keywords: mri fluid; reveal determinants; alzheimer disease; biomarkers reveal; fluid biomarkers; determinants myelin

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2023

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