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C9orf72 expansions are the most common cause of genetic frontotemporal dementia in a Southeast Asian cohort

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Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative disorders, including behavioural variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non‐fluent variant PPA (nfvPPA). While a strong genetic component… Click to show full abstract

Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative disorders, including behavioural variant FTD (bvFTD), semantic variant primary progressive aphasia (svPPA) and non‐fluent variant PPA (nfvPPA). While a strong genetic component is implicated in FTD, genetic FTD in Asia is less frequently reported. We aimed to investigate the frequency of Southeast Asian FTD patients harbouring known genetic FTD variants.

Keywords: southeast asian; frontotemporal dementia; c9orf72 expansions; ftd

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2023

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