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Therapeutic strategies for patients with febrile infection‐related epilepsy syndrome (FIRES) are limited, ad hoc, and frequently ineffective. Based on evidence that inflammation drives pathogenesis in FIRES, we used ex vivo… Click to show full abstract
Therapeutic strategies for patients with febrile infection‐related epilepsy syndrome (FIRES) are limited, ad hoc, and frequently ineffective. Based on evidence that inflammation drives pathogenesis in FIRES, we used ex vivo stimulation of peripheral blood mononuclear cells (PBMCs) to characterize the monocytic response profile before and after therapy in a child successfully treated with dexamethasone delivered intrathecally six times between hospital Day 23 and 40 at 0.25 mg/kg/dose.
Keywords:
associated hyperinflammatory;
hyperinflammatory monocytes;
monocytes fires;
drug resistant;
seizures associated;
resistant seizures
Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2023
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Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!