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Aging related cognitive changes associated with Alzheimer's disease in Down syndrome

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Individuals with Down syndrome (DS) have an extremely high genetic risk for Alzheimer's disease (AD), however, the course of cognitive decline associated with progression to dementia is ill‐defined. Data‐driven methods… Click to show full abstract

Individuals with Down syndrome (DS) have an extremely high genetic risk for Alzheimer's disease (AD), however, the course of cognitive decline associated with progression to dementia is ill‐defined. Data‐driven methods can estimate long‐term trends from cross‐sectional data while adjusting for variability in baseline ability, which complicates dementia assessment in those with DS.

Keywords: alzheimer disease; disease; aging related; related cognitive; changes associated; cognitive changes

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2018

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