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Cervical skin denervation associates with alpha‐synuclein aggregates in Parkinson disease

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Autonomic nervous system is involved at the onset of Parkinson disease (PD), and alpha‐synuclein (α‐Syn) and its phosphorylated form (p‐αSyn) have been detected in dermal autonomic nerve fibers of PD.… Click to show full abstract

Autonomic nervous system is involved at the onset of Parkinson disease (PD), and alpha‐synuclein (α‐Syn) and its phosphorylated form (p‐αSyn) have been detected in dermal autonomic nerve fibers of PD. We assessed disease specific conformation variant of α‐Syn immunoreactivity in cutaneous nerves and characterized skin denervation patterns in PD and atypical parkinsonism (AP).

Keywords: alpha synuclein; skin denervation; disease; parkinson disease

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2018

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