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IVIg‐induced plasmablasts in patients with Guillain‐Barré syndrome

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The Guillain–Barré syndrome (GBS) is an acute, immune‐mediated disease of peripheral nerves. Plasmablasts and plasma cells play a central role in GBS by producing neurotoxic antibodies. The standard treatment for… Click to show full abstract

The Guillain–Barré syndrome (GBS) is an acute, immune‐mediated disease of peripheral nerves. Plasmablasts and plasma cells play a central role in GBS by producing neurotoxic antibodies. The standard treatment for GBS is high‐dose intravenous immunoglobulins (IVIg), however the working mechanism is unknown and the response to treatment is highly variable. We aimed to determine whether IVIg changes the frequency of B‐cell subsets in patients with GBS.

Keywords: plasmablasts patients; guillain barr; patients guillain; induced plasmablasts; barr syndrome; ivig induced

Journal Title: Annals of Clinical and Translational Neurology
Year Published: 2019

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